Synthesis of Unnatural Amino Acids Functionalized with Sterically Shielded Pyrroline Nitroxides
نویسندگان
چکیده
A series of unnatural amino acids functionalized with sterically shielded pyrroline nitroxides were synthesized. Their reduction by ascorbate/glutathione indicates that L-cysteine functionalized with gem-diethylpyrroline nitroxide is reduced at the slowest rate and is comparable to that measured for the most resistant to reduction pyrroline and pyrrolidine nitroxides.
منابع مشابه
Synthesis and reduction kinetics of sterically shielded pyrrolidine nitroxides.
A series of sterically shielded pyrrolidine nitroxides were synthesized, and their reduction by ascorbate (vitamin C) indicate that nitroxide 3, a tetraethyl derivative of 3-carboxy-PROXYL, is reduced at the slowest rate among known nitroxides, i.e., at a 60-fold slower rate than that for 3-carboxy-PROXYL.
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عنوان ژورنال:
دوره 16 شماره
صفحات -
تاریخ انتشار 2014